【学术】按需溶解水凝胶敷料的研究新进展

发布时间：2019-01-07 10:17:08 点击量:

邓君 教授

陆军军医大学烧伤研究所

Burns & Trauma推荐文章

引用格式： Lu H, Yuan L, Yu X, Wu C, He D, Deng J. Recent advances of on-demand dissolution of hydrogel dressings. Burns Trauma 2018, 6:35

划重点啦-highlights

1、按需溶解水凝胶具有独特的原位形成能力，可通过物理或化学反应按需溶解。

2、可溶解交联水凝胶的制备策略为按需溶解水凝胶的制备和体内应用提供方法。

3、溶解策略的不断探索将揭示新的溶解机制，扩大水凝胶敷料的应用范围。

皮肤创伤是正常组织的解剖与生理功能受到破坏的结果。皮肤创伤后会引起各种损害，如新陈代谢加剧、体温下降、水分和蛋白质的过度散失及内分泌和免疫系统的失调。很多慢性伤口严重影响着患者的生活质量甚至危及生命。伤口愈合与伤口护理是一个重大的全球性挑战，许多人致力于研究促进伤口愈合的新的有效的策略，包括按需溶解的水凝胶。按需溶解的水凝胶可以在外加溶解剂或外界刺激下发生溶解，轻易的从创面清除避免传统的更换敷料对伤口造成二次损伤。

陆军军医大学烧伤研究所邓君教授课题组总结了近年来按需溶解水凝胶的研究进展，包括化学交联和物理交联按需溶解水凝胶的交联和溶解策略，详细介绍了按需溶解水凝胶的分类及其应用情况，为新型按需溶解水凝胶敷料的设计提供依据，这些研究结果可能对难以愈合的创面具有潜在的治疗意义。

Abstract：

Wound management is a major global challenge and a big financial burden to the healthcare system due to the rapid growth of chronic diseases including the diabetes, obesity, and aging population. Modern solutions to wound management include hydrogels that dissolve on demand, and the development of such hydrogels is of keen research interest. The formation and subsequent on-demand dissolution of hydrogels is of keen interest to scientists and clinicians. These hydrogels have excellent properties such as tissue adhesion, swelling, and water absorption. In addition, these hydrogels have a distinctive capacity to form in situ and dissolve on-demand via physical or chemical reactions. Some of these hydrogels have been successfully used as a dressing to reduce bleeding in hepatic and aortal models, and the hydrogels remove easily afterwards. However, there is an extremely wide array of different ways to synthesize these hydrogels. Therefore, we summarize here the recent advances of hydrogels that dissolve on demand, covering both chemical cross-linking cases and physical cross-linking cases. We believe that continuous exploration of dissolution strategies will uncover new mechanisms of dissolution and extend the range of applications for hydrogel dressings.